Photodynamic Therapy

Levulan® Photodynamic Treatment (PDT) For Acne & Aging Skin

Photodynamic therapy was originally developed for the treatment of cancer. We now know there are a number of other clinical conditions which can respond effectively to this exciting procedure.

The cause of acne is multifactorial. The bacterium P. acnes are responsible for the majority of cases of acne, which is also aggravated by excessive sebum production by sebaceous glands. Levulan® is absorbed in sebaceous glands, which also play a role in the cause of acne. Recent studies have shown that treatments using topically applied Levulan® followed by light activation have resulted in dramatic improvement in the severity of patients' acne.

There were no serious adverse events noted with the topical use of Levulan®, however patients do experience some mild redness and fine crusting after treatment.

While the use of Levulan® photodynamic therapy to treat acne is a new modality, it clearly shows great promise in producing long term remission and clearance in this troublesome disease.

Another promising area for Levulan® use appears to be in the treatment of photo-aged skin. Patients with sun-damaged skin have been treated with topically applied Levulan® followed by light treatment. Patients noted the appearance of reduced pore size and an improvement in pigment abnormalities and textural quality.

Frequently Asked Questions

How does Photodynamic Therapy (PDT) Work?

In photodynamic therapy a photosensitizer (Levulan®) is applied to the skin. This is absorbed preferentially by certain structures in the skin, such as hair follicles, oil glands, bacteria, or rapidly growing cells. Illumination with a high-intensity light or lasers causes a reaction in the skin, resulting in destruction of the targeted tissue.

What Types of Conditions can be Treated with PDT?

Photodynamic therapy has been effective in the treatment of actinic keratoses (pre-cancerous spots), sun damaged skin, acne, warts, and many other diseases.

How Does PDT Treat Acne?

Photodynamic therapy seems to treat acne by decreasing the bacteria on the skin and by shrinking the oil-producing sebaceous glands.

Is PDT Uncomfortable?

During PDT the skin is washed several times and the activated substance is applied. Either of these may cause stinging. Following treatment there may be some transient itching and a mild sunburn sensation.

Photosensitivity

After PDT, a small amount of activated substance remains in the skin for 24 to 48 hours. Sunlight and even indoor light may affect this and cause redness and itching. Use of sunscreen and a hat may diminish these undesired effects.

Itching/Burning

Most people experience mild burning or itching for about one hour after the procedure, although this can last a day or two. Mild to moderate redness may be experienced for 24 to 48 hours. Only gentle emollients should be applied to the skin.

Swelling

Areas most likely to swell are around the eyes. This will subside within several hours. Application of ice or cold packs may help.

Peeling

Peeling of treated skin may occur several days after the procedure and can be alleviated by gentle washing and application of a slightly thicker moisturizer.

Consult your doctor if any of these side effects seem severe or cause significant discomfort.